53Biologics has been featured in the latest edition of APTE Technonews (Issue 91), the magazine of the Spanish Association of Science and Technology Parks. The article highlights our contribution to innovation in RNA enzyme manufacturing. This is a cornerstone technology enabling mRNA vaccines, gene therapy and next-generation RNA-based treatments.
The challenge of RNA enzyme manufacturing
RNA-based therapeutics rely on high-performance enzymes such as RNA polymerase, essential for accurate RNA synthesis. However, manufacturing these enzymes at industrial scale poses major challenges related to purity, catalytic activity and scalability. Optimizing expression, purification and formulation conditions is critical to ensure consistent performance and regulatory compliance.
53Biologics: A partner in RNA innovation
As a CDMO specialized in biologics production from DNA to proteins, 53Biologics has developed a flexible and scalable approach for RNA enzyme manufacturing. The company has improved process flexibility, minimized cross-contamination risks and enhanced production efficiency.
Our facilities support multiple production scales, from 500 L non-GMP to 200 L and 2,000 L GMP batches. This allows us to adapt to each client’s project stage and regulatory pathway. This modularity ensures seamless transitions from preclinical development to full GMP manufacturing.
Driving the future of RNA-based therapies
Ongoing R&D at 53Biologics focuses on improving enzyme stability, catalytic efficiency and formulation to expand their use in RNA-based therapies, vaccines, and genetic-editing tools. With our experience and technological capabilities, we continue to support the development of more accessible and effective RNA therapeutics worldwide.
🔗 Read the full article in APTE Technonews (page 44): https://www.apte.org/revista-apte-techno-91/
About us:
53Biologics is a Spanish CDMO specialized in decoding biologics production, from DNA to proteins. The company provide services from preclinical development to GMP manufacturing, supporting their clients in getting their biological products to market as quickly as possible.
For more information or to speak with one of our experts, fill out our contact form or email us at in**@53*********.com.
