Pichia pastoris is a methylotrophic yeast which is known as one of the most versatile recombinant expression host system.
One of its positive points of Pichia as recombinant production host for the pharma & diagnostic sector is to be more similar with advanced eukaryotic expression systems such as CHO or HEK cell lines. For example, Pichia can add posttranslational modifications like glycosylation that sometimes are needed for the correct folding, solubility, stability, and proper biological activity of your protein of interest.
Besides this, Pichia pastoris has also some competitive advantages like its ability to secrete extracellularly your protein of interest surrounded by a reduced amount of HCP, reduced fermentation times and media production costs with also a strong portfolio of molecular tools to obtain your desired yields.
Those benefits make Pichia one of the preferred microbial platform to overexpress protein of interest. In a few weeks 53Biologics would carry out a lean proof of concept to demonstrate the overexpression of your protein of interest in Pichia and to predict potential rooms for improvement that could guide subsequent development programs.