From E. coli to P. pastoris and fungal systems, we designs the most suitable microbial host for your recombinant protein production
We can find the most suitable microbial host for your target protein. Our team helps you identify and engineer the most suitable microbial host for your protein, using IP-free molecular biology tools, robust analytics, and GMP-ready processes. Whether you need fast prototyping, high-yield production, or complex protein expression, we provide tailor-made solutions to meet your program’s needs.
We advise and support our clients in choosing the most promising host for each specific case
E. coli remains the most widely used microbial system for recombinant protein expression. Its well-characterized biology and regulatory acceptance make it the ideal host for fast, cost-efficient projects. At 53Biologics we provide engineered E. coli strains, optimized plasmids, and high-throughput workflows to maximize protein productivity while minimizing timelines to clinic.
Our expertise in yeast expression systems, particularly P. pastoris, allows us to produce recombinant proteins with high yield and scalability. Using advanced molecular tools (promoters, signal peptides, secretion sequences, helpers factors, etc…) to obtain your recombinant protein. We use the most advanced and IP free molecular biology tools to bring out the full potential of yeasts.
Fungal platforms have demonstrated the highest potential in terms of protein productivity, complexity and efficiency. 53Biologics is the world-wide CDMO leader developing fungal strains Trichoderma, Aspergillus or the revolutionary Myceliophthora termophila, nicknamed C1 and transferring production processes to the industry.
Global-Standard Facilities and Quality
With over 25 successful audits in the last two years, EMA manufacturing authorization, and a robust QMS (21 CFR & Eudralex vol.4 compliant), 53Biologics ensures your microbial projects are developed under the highest international quality standards.
From aminoacid sequence to strain to GMP MCB fully characterized for GMP production, our experts support you through every step.
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