Trust in our ability to develope high-yielding production strains of E. coli, P. pastoris and fungi
Whether you need fast prototyping, high-yield production or complex protein expression, we provide host selection and engineering to develop your tailor-made production strain.
The well-characterized biology and regulatory acceptance of E. coli make it the ideal host for fast, cost-efficient projects. At 53Biologics we provide engineered E. coli strains, optimized plasmids and high-throughput workflows to maximize protein productivity while minimizing timelines to clinic.
Our expertise in yeast expression systems, particularly P. pastoris, allows us to produce recombinant proteins with high yield and scalability. Using advanced molecular tools (promoters, signal peptides, secretion sequences, helpers factors, etc…) to obtain your recombinant protein. We use the most advanced and IP free molecular biology tools to bring out the full potential of yeasts.
Fungal platforms have demonstrated the highest potential in terms of protein productivity, complexity and efficiency. 53Biologics is the world-wide CDMO leader developing fungal strains Trichoderma, Aspergillus or the revolutionary Myceliophthora termophila, nicknamed C1 and transferring production processes to the industry.
From aminoacid sequence to strain to GMP MCB fully characterized for GMP production, our experts support you through every step.
Gene & plasmid design
Design of plasmids for maximum protein expression
Strain engineering and screening
Selection of the most suitable cells and RCB development
Cell bank generation
WCB/MCB generation and characterization with long-term storage available
Process Development
Common challenges, such as low expression or inclusion bodies, are addressed
53Biologics ensures your microbial projects are developed under the highest international quality standards
25
successful audits in the last two years
EMA
manufacturing authorization
QMS
21 CFR & Eudralex vol.4 compliant
Discover more about 53Biologics protein services
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